21 Adverse Effects
Adverse effects:
Common ( e.g. > 10%), rare
Add: APAP, non-acetylated salicylates, baclofen, tizanidine, oxcarbazepine & carbamazepine
| Organs and Systems | NSAIDs | Opioids | Gabapentinoids | SNRIs | TCAs | |||
Kidneys  |
Acute renal failure, interstitial nephritis, nephrotic syndrome | |||||||
Liver  |
Transaminase elevations, rare severe hepatic reactions | |||||||
Heart  |
[1] | |||||||
Lungs  |
||||||||
GI Tract  |
Ulceration, bleeding, perforation of stomach or intestines | |||||||
Platelets/Coagulation  |
Inhibits platelet function | |||||||
Skin/Musculoskeletal  |
Exfoliative dermatitis, SJS/TEN | |||||||
Central Nervous System  |
Drowsiness, dizziness, blurred vision | |||||||
Peripheral Nervous System  |
||||||||
Endocrine System  |
||||||||
Immune System  |
| Ketorolac |
| Salsalate |
| Meloxicam |
| Gabapentin & Pregabalin |
| Duloxetine |
| Carbamazepine & Oxcarbazepine |
| Desipramine |
| Topiramate |
| Acetaminophen |
| Baclofen |
| Tizanidine |
| Fentanyl |
| Methadone |
| Oxycodone & Oxymorphone |
| Morphine & Hydromorphone |
| Tapentadol |
- Thrombotic events (MI, stroke) ↵
