21 Adverse Effects
Adverse effects:
Common ( e.g. > 10%), rare
Add: APAP, non-acetylated salicylates, baclofen, tizanidine, oxcarbazepine & carbamazepine
Organs and Systems | NSAIDs | Opioids | Gabapentinoids | SNRIs | TCAs | |||
Kidneys | Acute renal failure, interstitial nephritis, nephrotic syndrome | |||||||
Liver | Transaminase elevations, rare severe hepatic reactions | |||||||
Heart | [1] | |||||||
Lungs | ||||||||
GI Tract | Ulceration, bleeding, perforation of stomach or intestines | |||||||
Platelets/Coagulation | Inhibits platelet function | |||||||
Skin/Musculoskeletal | Exfoliative dermatitis, SJS/TEN | |||||||
Central Nervous System | Drowsiness, dizziness, blurred vision | |||||||
Peripheral Nervous System | ||||||||
Endocrine System | ||||||||
Immune System |
Ketorolac |
Salsalate |
Meloxicam |
Gabapentin & Pregabalin |
Duloxetine |
Carbamazepine & Oxcarbazepine |
Desipramine |
Topiramate |
Acetaminophen |
Baclofen |
Tizanidine |
Fentanyl |
Methadone |
Oxycodone & Oxymorphone |
Morphine & Hydromorphone |
Tapentadol |
- Thrombotic events (MI, stroke) ↵