Blood Glucose Monitoring

Routine glucose monitoring: 

Routine blood glucose monitoring with a bedside point-of-care (POC) glucometer is needed for all patients admitted to the hospital with insulin-dependent diabetes mellitus (e.g. T1DM, T2DM, CF-related DM, etc.).

Routine blood glucose monitoring is performed 9 times per day at the following “protocolized” times:

  1. Within 15-30 minutes before meals (3 x per day)
    • These are preprandial blood sugars
  1. Two hours after each meal (3 x per day)
    • These are postprandial blood sugars
  2. “Bedtime” (~2100)
  3. Midnight (0000)
  4. 3 AM (0300)
The timing of routine blood glucose monitoring and insulin administration within the hospital is demonstrated in Figure 1.
Figure 1 – Routine blood glucose monitoring occurs a minimum of 9 times per day in the hospital. A basal/bolus insulin regimen with MDI therapy is depicted in which long-acting insulin (blue) has action overnight. Rapid-acting insulin (green) has action in the 2-4 hours after injection and affects the pre-prandial blood sugars of the next meal.

Inpatient blood glucose monitoring for patients with non-insulin-dependent Type 2 diabetes usually includes:

  1. Fasting AM blood glucose prior to breakfast
  2. A 2-hour postprandial blood glucose after lunch or dinner

A Note on CGMs:

  • CGMs are not currently FDA approved for inpatient use as the accuracy of these devices may be drastically impacted by acute illness (patients are in a state of disequilibrium) and various medications.
    • If a patient is allowed to continue wearing their CGM:
      • POC blood glucose must also be obtained and logged by nursing during their admission as CGM readings may not be reliable.
      • Additional POC blood glucose checks are needed to confirm alarms/alerts by the device.
  • CGMs must be removed prior to MRIs and prior to x-ray radiation (CT or X-rays)
Blood Glucose Monitoring in Special Circumstances:

The frequency of bedside blood glucose monitoring by POC blood glucose checks changes under the following conditions:

Table 1 – Two-bag system titration chart. The ratio of the two-bag system used for patients on an insulin drip is titrated based on hourly blood glucose to maintain blood glucose in a range of 100-250 mg/dL.

Additional blood glucose checks may be needed outside of the routine checks that were discussed above.

Keep the following rules of thumb in mind and you will never go wrong:

Blood Glucose Checks at “Non-protocolized” times:

  1. When in doubt, check a blood sugar
    • It is always safer to check blood sugar more often (or sooner than the next scheduled check) if you have clinical doubts or concerns about a patient
  2. Before ANY rapid-acting insulin administration
    • This includes any non-protocolized insulin administration
    • It is always safer to determine where the blood sugar is starting from as it may help guide how much insulin is to be given and the timing of the follow-up blood glucose check
  3. 2-3 Hours AFTER any rapid-acting insulin administration
    • This includes insulin delivered at non-protocolized times or insulin given for ketone corrections
    • Why?
      • Rapid-acting insulin’s peak action time is 1-2 hours and the duration of action is 3-4 hours after administration. Checking a blood sugar 2-3 hours after insulin administration allows you to see how the patient’s blood sugar “responds” to the dose that was given and monitors for the development of hypoglycemia.
  4. For any symptoms of hypoglycemia or severe hyperglycemia or ketosis
    • Hypoglycemia should be treated immediately if present
    • Hyperglycemia, if causing significant symptoms should be addressed and the patient should check for the presence of ketones

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